EONIS™ Platform

Simultaneous multiplexing of SMA, SCID & XLA screening from a single DBS punch

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OVERVIEW

EONIS™ PLATFORM

Multiplexing of SMA, SCID and XLA screening can now be done in one assay utilizing Real-Time PCR technology, with­out increasing daily hands-on workload and complexity. This will provide a future-proof solution for cost-efficiently obtaining additional disorder information.

Combination of DNA extraction, multiplexing and auto­mation allows maximum efficiency in workflow. Analytes are quantified using innovative analysis method without calibrators, saving more room for your samples. For maximum flexibility and throughput, as well as for minimum hands-on time, liquid handling can be used both for DNA Extraction and for PCR setup in the Eonis™ platform.

Instrument
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Achieve accurate results easily

Workflow

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Punching

The 3.2 mm punches used in the Eonis SCID-SMA Assay can be punched directly from a dried blood spot (DBS) specimen card to a DNA Extraction Plate with either the DBS or the Panthera Puncher.

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DNA Extraction

The Eonis DNA Extraction kit provides an effective solution for extracting and purifying DNA from a DBS disk for molecular assays. This can be performed manually or automatically using a liquid handler such as PerkinElmer JANUS®

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Amplification

Amplification reaction is set up with the reagents provided in the Eonis SCID-SMA kit.

LifeCycle screens

Data Analysis

Data analysis is performed with a dedicated Eonis Analysis software.

Eonis system Instruments

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JANUS® Extraction Instrument and JANUS® Mini Extraction instrument

Janus Liquid Handler can be used for automatic pipetting while extracting DNA  from DBS. The samples are handled with Janus Extraction Instrument that can process four 96-well plates simultaneously while Janus Mini Extraction is designed for smaller and medium throughput labs with one plate extraction at time.

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JANUS® PCR mastermix instrument

For customers running PCR with 384-well format, mastermix setup is automated with the Janus PCR mastermix instrument. This enables minimal manual intervention in the workflow.

Three analytes (TREC, KREC, SMN1 exon 7) and an internal amplification control (RPP30) is detected simultaneously by an RT-qPCR instrument with target sequence-specific primers and probes containing different fluorescent dyes.

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QuantStudio™ Dx Real-Time PCR instrument

QuantStudioTM Dx instrument supports running PCR in 96-well or 384-well mode depending on the instrument configuration.

OVERVIEW

Kits available for the Eonis Platform

Kits

EONIS™ DNA Extraction kit

EONIS™ SCID-SMA kit

Laboratory Management at your finger tips

SOFTWARE
Analyze at scale
SOFTWARE

Specimen Gate® software

Newborn screening software that provides control and monitoring tools for the entire screening process.

Specimen Gate software is designed to simplify the data collection and workflow processes
involved with receiving specimens, screening for abnormalities, managing patient information, generating specimen reports, and following up abnormal and unsatisfactory specimens.

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Laboratory Equipment no matter your size or sophistication

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Instruments
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Tandem Mass Spectrometry – QSight®

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Panthera Puncher™ 9 – Panthera DBS Puncher

Panthera Puncher™ 9 – Panthera DBS Puncher

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DBS Puncher

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Migele™ Gel Electrophoresis Unit

Migele™ Gel Electrophoresis Unit

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Articles & Resources

Articles & Resources

Articles & Resources
Article News
First SMA baby identified with our screening solutions in Australia
Newborn
26 Apr 2021

First SMA baby identified with our screening solutions in Australia

A newborn baby has been identified as having SMA (spinal muscular atrophy) in Westmead Children’s Hospital in Australia, using a 4-plex SMA, SCID and XLA laboratory developed test
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Webinar
Idario Santos – Sweet Odyssey
Newborn
22 Apr 2021

Idario Santos – Sweet Odyssey

Idario Santos - talks about his sons journey with Maple Syrup Urine Disease - Sweet Odyssey
Learn More
Interview
Expanded newborn screening – An interview with Dr. Marianna Messina
Newborn
22 Apr 2021

Expanded newborn screening – An interview with Dr. Marianna Messina

Dr. Marianna Messina discusses her experiences introducing expanded screening to her laboratory in Italy.
Learn More
More resources

Products may not be licensed in accordance with the laws in all countries, such as the United States and Canada. Please check with your local representative for availability.

 

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