EONIS™ System

Simultaneous multiplexing of SMA, SCID & XLA screening from a single DBS punch

OVERVIEW

EONIS™ SYSTEM

Multiplexing of SMA, SCID and XLA screening can now be done in one assay utilizing Real-Time PCR technology, with­out increasing daily hands-on workload and complexity. This will provide a future-proof solution for cost-efficiently obtaining additional disorder information.

Combination of DNA extraction, multiplexing and auto­mation allows maximum efficiency in workflow. Analytes are quantified using innovative analysis method without calibrators, saving more room for your samples. For maximum flexibility and throughput, as well as for minimum hands-on time, liquid handling can be used both for DNA Extraction and for PCR setup in the Eonis™ platform.

Instrument
web_EONISiStock-640071044 ellipse icon

Achieve accurate results easily

Workflow

6Y8O7109_HDR2

Punching

The 3.2 mm punches used in the Eonis SCID-SMA Assay can be punched directly from a dried blood spot (DBS) specimen card to a DNA Extraction Plate with either the DBS or the Panthera Puncher.

circular_dna_182134976

DNA Extraction

The Eonis DNA Extraction kit provides an effective solution for extracting and purifying DNA from a DBS disk for molecular assays. This can be performed manually or automatically using a liquid handler such as PerkinElmer JANUS®

pe-mdx-ja-msms-028_web

Amplification

Amplification reaction is set up with the reagents provided in the Eonis SCID-SMA kit.

LifeCycle screens

Data Analysis

Data analysis is performed with a dedicated Eonis Analysis software.

Eonis system Instruments

JANUS_G3_NGS_Express_Worksation

JANUS® Extraction Instrument and JANUS® Mini Extraction instrument

Janus Liquid Handler can be used for automatic pipetting while extracting DNA  from DBS. The samples are handled with Janus Extraction Instrument that can process four 96-well plates simultaneously while Janus Mini Extraction is designed for smaller and medium throughput labs with one plate extraction at time.

Janus_with_varispan_and_MDT

JANUS® PCR mastermix instrument

For customers running PCR with 384-well format, mastermix setup is automated with the Janus PCR mastermix instrument. This enables minimal manual intervention in the workflow.

Three analytes (TREC, KREC, SMN1 exon 7) and an internal amplification control (RPP30) is detected simultaneously by an RT-qPCR instrument with target sequence-specific primers and probes containing different fluorescent dyes.

QuantStudio Dx - Left Facing

QuantStudio™ Dx Real-Time PCR instrument

QuantStudioTM Dx instrument supports running PCR in 96-well or 384-well mode depending on the instrument configuration.

OVERVIEW

Kits available for the Eonis system

Kits

EONIS™ DNA Extraction kit

EONIS™ SCID-SMA kit

Laboratory Management at your finger tips

SOFTWARE
Analyze at scale
SOFTWARE

Specimen Gate® software

Newborn screening software that provides control and monitoring tools for the entire screening process.

Specimen Gate software is designed to simplify the data collection and workflow processes
involved with receiving specimens, screening for abnormalities, managing patient information, generating specimen reports, and following up abnormal and unsatisfactory specimens.

Laboratory Equipment no matter your size or sophistication

More Newborn Screening Instruments

Instruments
GSP® Instrument

GSP® Instrument

Automated platform for screening of NBS disorders, the GSP® Newborn screening system offers outstanding screening accuracy and reliability, coupled with high efficiency and user-friendliness.
AutoDELFIA® immunoassay system

AutoDELFIA® immunoassay system

AutoDELFIA® immunoassay system for prenatal & neonatal screening with fully automated batch-loading
VICTOR2™ D fluorometer

VICTOR2™ D fluorometer

Fluorometer designed for clinical use with all PerkinElmer diagnostic and screening assays based on either time-resolved fluorescence or prompt fluorescence.
QSight® MD Screening Systems

QSight® MD Screening Systems

The QSight® MD mass spectrometry screening systems are designed for routine high throughput quantitation. They offer expanded screening for a variety of inborn errors of metabolism with a wide analyte panel, and access to Tier 2 chromatography (QSight® 225 MD UHPLC only).
Panthera Puncher™ 9 Instrument

Panthera Puncher™ 9 Instrument

Panthera Puncher™ 9 is the new generation dried sample punching device for automatically punching dry blood spot samples into microtitration plates.
PerkinElmer 226 Sample collection device

PerkinElmer 226 Sample collection device

The PerkinElmer 226 Sample Collection Device offers a minimally invasive technique for Dried Blood Sample (DBS) collection
DBS Puncher

DBS Puncher

DBS Puncher Instrument is an automated device for punching dried blood spot samples into microtitration plates. The 2-plate capacity puncher is an easy-to-use, robust option for lower capacity screening.
Migele™ Gel Electrophoresis Unit

Migele™ Gel Electrophoresis Unit

Migele™ Gel Electrophoresis Unit works with the RESOLVE™ hemoglobin kit to detect hemoglobinopathies in newborns and adults, including sickle cell disease and other hemoglobin variants and thalassemias.
Articles & Resources

Articles & Resources

Articles & Resources
First SMA baby identified with our screening solutions in Australia
Newborn
26 Apr 2021

First SMA baby identified with our screening solutions in Australia

A newborn baby has been identified as having SMA (spinal muscular atrophy) in Westmead Children’s Hospital in Australia, using a 4-plex SMA, SCID and XLA laboratory developed test
Idario Santos – Sweet Odyssey
Newborn
22 Apr 2021

Idario Santos – Sweet Odyssey

Idario Santos - talks about his sons journey with Maple Syrup Urine Disease - Sweet Odyssey
Expanded newborn screening – An interview with Dr. Marianna Messina
Newborn
22 Apr 2021

Expanded newborn screening – An interview with Dr. Marianna Messina

Dr. Marianna Messina discusses her experiences introducing expanded screening to her laboratory in Italy.
GET IN TOUCH

Take the next step

GET IN TOUCH

Speak with a sales person

Talk to one of our product experts about the right solutions for you.

Contact us today

View more resources

Explore our articles and resources section for the latest information

Learn More

Read the lastest news

Sign up for our newsletter to find out about the latest news from PerkinElmer and the industry

Learn More
GET IN TOUCH

Take the next step

GET IN TOUCH

Speak with a sales person

Talk to one of our product experts about the right solutions for you.

Contact us today

View more resources

Explore our articles and resources section for the latest information

Learn More

Read the lastest news

Sign up for our newsletter to find out about the latest news from PerkinElmer and the industry

Sign up
shutterstock_1689772501 1

Find out the latest news

Join our email list for industry news, webinars and the latest information about PerkinElmer’s solutions for Reproductive Health

Products may not be licensed in accordance with the laws in all countries, such as the United States and Canada. Please check with your local representative for availability.