With our high-throughput Vanadis® NIPT solution, we’re taking all the complexity out of noninvasive prenatal testing, making it accessible to more women – and more cost-effective for your laboratory. This breakthrough cell-free DNA (cfDNA) technology eliminates PCR amplification and gene sequencing, and it’s so easy to use that one laboratory technician can handle 2000 to 20 000 samples per year. Walkaway automation streamlines the process from primary tube to final results. Because the Vanadis system is an easy to use, non-NGS and non-PCR based method, any laboratory can use it.
Streamlined workflow from primary tube to final result
Screen for the risk of trisomies 21, 18, 13, as well as fetal sex determination with Vanadis NIPT. By targeting thousands of chromosomal sequences, the Vanadis system can bring high precision non-invasive prenatal testing to your lab, counting an average of 650,000 molecules per chromosome.
The Vanadis Extract platform automatically performs plasma separation and cfDNA extraction and purification.
Thousands of targeted cfDNA fragments are specifically converted to DNA circles. Circles are converted to fluorescent DNA molecules and labeled with chromosome-specific fluorophores. The labeled fluorescent DNA molecules are deposited to a microfilter plate.
The fluorescent DNA molecules are deposited on the Vanadis View® plate and counted with the Vanadis View® instrument. With image analysis algorithms, the fluorescent DNA molecules are counted for each sample.
The ratio between the number of each chromosome-specific fluorescent DNA molecules is transferred for risk calculation to the LifeCycle™ Prenatal Screening Software, to calculate the likelihood of a trisomy.
Walkaway automation for greater efficiency
With Vanadis technology, all the critical steps are automated, starting with pipetting steps to reduce manual errors. Plasma volumes are monitored by camera to avoid contamination by the buffy coat, and samples and reagents are barcoded for complete tracking throughout the workflow. Our software guides you through the process, with user-friendly touchscreens, enabling remote workflow management for ease of use. Easy to integrate, our software is designed for LIMS connectivity, reducing manual errors while simplifying data management.
No PCR, No sequencing
Vanadis is the only NIPT screening platform to enable targeted cfDNA analysis without PCR, instead directly capturing target fragments and labeling them for counting. A proprietary nanofilter plate then captures labeled molecules for imaging, eliminating the need for data-intensive steps such as DNA sequencing, microarrays, and microfluidics.
Leading risk calculation software
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Articles & Resources
Prenatal screening for trisomy 21: a comparative performance and cost analysis of different screening strategies
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Products may not be licensed in accordance with the laws in all countries, such as the United States and Canada. Please check with your local representative for availability.
Vanadis NIPT is used for screening for the risk of trisomy 21, 18, and/or 13. The reporting of fetal sex determination is an optional feature, not offered in countries where such reporting is not permitted such as India. Please check with your local representative for availability.
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