Vanadis® NIPT system

A Whole New Way to NIPT

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OVERVIEW

With our high-throughput Vanadis® NIPT solution, we’re taking all the complexity out of noninvasive prenatal testing, making it accessible to more women – and more cost-effective for your laboratory. This breakthrough cell-free DNA (cfDNA) technology eliminates PCR amplification and gene sequencing, and it’s so easy to use that one laboratory technician can handle 2000 to 14 000 samples per year. Walkaway automation streamlines the process from primary tube to final results. Because the Vanadis system is an easy to use, non-NGS and non-PCR based method, any laboratory can use it.

Instrument

PERSPECTIVES ON VANADIS

Customer experiences with Vanadis NIPT

PERSPECTIVES ON VANADIS

WORKFLOW

Streamlined workflow from primary tube to final result

Screen for the risk of trisomies 21, 18, 13, as well as fetal sex determination with Vanadis NIPT. By targeting thousands of chromosomal sequences, the Vanadis system can bring high precision non-invasive prenatal testing to your lab, counting an average of 650,000 molecules per chromosome.

WORKFLOW

Vanadis Extract®

The Vanadis Extract platform automatically performs plasma separation and cfDNA extraction and purification.

Vanadis Core®

Thousands of targeted cfDNA fragments are specifically converted to DNA circles. Circles are converted to fluorescent DNA molecules and labeled with chromosome-specific fluorophores. The labeled fluorescent DNA molecules are deposited to a microfilter plate.

Vanadis View®

The fluorescent DNA molecules are deposited on the Vanadis View® plate and counted with the Vanadis View® instrument. With image analysis algorithms, the fluorescent DNA molecules are counted for each sample.

LifeCycle™ 7.0

The ratio between the number of each chromosome-specific fluorescent DNA molecules is transferred for risk calculation to the LifeCycle™ Prenatal Screening Software, to calculate the likelihood of a trisomy.

Walkaway automation for greater efficiency

With Vanadis technology, all the critical steps are automated, starting with pipetting steps to reduce manual errors. Plasma volumes are monitored by camera to avoid contamination by the buffy coat, and samples and reagents are barcoded for complete tracking throughout the workflow. Our software guides you through the process, with user-friendly touchscreens, enabling remote workflow management for ease of use. Easy to integrate, our software is designed for LIMS connectivity, reducing manual errors while simplifying data management.

GROUNDBREAKING cfDNA TECHNOLOGY

No PCR, No sequencing

Vanadis is the only NIPT screening platform to enable targeted cfDNA analysis without PCR, instead directly capturing target fragments and labeling them for counting. A proprietary nanofilter plate then captures labeled molecules for imaging, eliminating the need for data-intensive steps such as DNA sequencing, microarrays, and microfluidics.

GROUNDBREAKING cfDNA TECHNOLOGY

BENEFITS FOR YOUR LABORATORY

Easy to use. Easy to learn

Walkaway automation minimizes hands-on time and allows for quicker test results, available within 2-3 days.

Scalable platform

Requiring only a single technician to run up to 14 000 samples per year, Vanadis empowers laboratories under ever-increasing workloads.

LifeCycle_WomaninLaboratory_v2_fullscreen_HR

High-precision technology

Designed to deliver high-precision measurements to improve the detection and false positive rates while minimizing the no-call rate.

KITS

Proven clinical performance

KITS

Clinical studies have demonstrated that the Vanadis NIPT system could improve detection and false positive rates, while minimizing the number of no-calls. Check the Vanadis list of publications.

Products comprising the Vanadis NIPT system are CE-marked in vitro diagnostic products in accordance with European directive 98/79/EC.

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SOFTWARE

Leading risk calculation software

SOFTWARE

LifeCycle™ 7.0 software

Vanadis® NIPT system includes System Software and trusted LifeCycle™ software, the complete data management solution for prenatal screening laboratories. With a simple and flexible user interface and a performance monitoring dashboard that enables access from any current Web browser, these software provide the reliability and support laboratories can rely on.

Learn more about LifeCycle™

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RESOURCES

Articles & Resources

Instruments

Clinical validation of a novel automated cell‐free DNA screening assay for trisomies 21, 13, and 18 in maternal plasma

Prenatal

19 Aug 2019

Clinical validation of a novel automated cell‐free DNA screening assay for trisomies 21, 13, and 18 in maternal plasma

Ericsson et al., Prenatal Diagnosis. 2019

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Prenatal

23 Nov 2020

Prenatal screening for trisomy 21: a comparative performance and cost analysis of different screening strategies

Huang et al., BMC Pregnancy and Childbirth, 2020. Provided by the Springer Nature SharedIt content-sharing initiative. No modifications were made on this material. https://creativecommons.org/licenses/by/4.0/

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Minimizing Patients’ Risk of Adverse Outcomes in NIPT

Prenatal

26 Sep 2020

Minimizing Patients’ Risk of Adverse Outcomes in NIPT

Lawrence Prensky, MS, LCGC, CCGC, discusses the challenges within NIPT on one of the biggest stages in prenatal health, the CoGEN 2020 World Conference.

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Products may not be licensed in accordance with the laws in all countries, such as the United States and Canada. Please check with your local representative for availability.

Vanadis NIPT is used for screening for the risk of trisomy 21, 18, and/or 13. The reporting of fetal sex determination is an optional feature, not offered in countries where such reporting is not permitted such as India. Please check with your local representative for availability.