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Vanadis® NIPT system

A Whole New Way to NIPT

OVERVIEW

With our high-throughput Vanadis® NIPT solution, we’re taking all the complexity out of cell-free DNA (cfDNA) testing, making it accessible to more women – and more cost-effective for your laboratory. This breakthrough technology eliminates PCR amplification and gene sequencing, and it’s so easy to use that one laboratory technician can handle 2000 to 20 000 samples per year. Walkaway automation streamlines the process from primary tube to final results. Because the Vanadis system is an easy to use, non-NGS and non-PCR based method,  any laboratory can use it.

Instrument
WHAT CUSTOMERS SAY ABOUT VANADIS

"Watching the system in action is amazing"

WHAT CUSTOMERS SAY ABOUT VANADIS
WORKFLOW

Streamlined workflow from primary tube to final result

WORKFLOW
VanadisExtract

Vanadis Extract®

The Vanadis Extract platform automatically performs plasma separation and cfDNA extraction and purification.

VanadisCore

Vanadis Core®

Thousands of targeted cfDNA fragments are specifically converted to DNA circles. Circles are converted to fluorescent DNA molecules and labeled with chromosome-specific fluorophores. The labeled fluorescent DNA molecules are deposited to a microfilter plate.

VanadisView

Vanadis View®

The fluorescent DNA molecules are deposited on the Vanadis View® plate and counted with the Vanadis View® instrument. With image analysis algorithms, the fluorescent DNA molecules are counted for each sample.

LifeCycle software 512x288px

LifeCycle™ 7.0

The ratio between the number of each chromosome-specific fluorescent DNA molecules is transferred for risk calculation to the LifeCycle™ Prenatal Screening Software, to calculate the likelihood of a trisomy.

Walkaway automation for greater efficiency

With Vanadis technology, all the critical steps are automated, starting with pipetting steps to reduce manual errors. Plasma volumes are monitored by camera to avoid contamination by the buffy coat, and samples and reagents are barcoded for complete tracking throughout the workflow.

GROUNDBREAKING cfDNA TECHNOLOGY

No PCR, No sequencing

Vanadis is the only NIPT screening platform to enable targeted cfDNA analysis without PCR, instead directly capturing target fragments and labeling them for counting. A proprietary nanofilter plate then captures labeled molecules for imaging, eliminating the need for data-intensive steps such as DNA sequencing, microarrays, and microfluidics.

GROUNDBREAKING cfDNA TECHNOLOGY
BENEFITS FOR YOUR LABORATORY
BENEFITS FOR YOUR LABORATORY
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Easy to use. Easy to learn

Walkaway automation minimizes hands-on time and allows for quicker test results, available within 2-3 days.

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Scalable platform

Requiring only a single technician to run up to 20 000 samples per year, Vanadis empowers laboratories under ever-increasing workloads.

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High-precision technology

Designed to deliver high-precision measurements to improve the detection and false positive rates while minimizing the no-call rate.

KITS

Proven clinical performance

Vanadis Core® T21/T18/T13 Reagent Cartridge

KITS

Clinical studies have demonstrated that the Vanadis NIPT system could improve detection and false positive rates, while minimizing the number of no-calls. Products comprising the Vanadis NIPT system are CE-marked in vitro diagnostic products in accordance with European directive 98/79/EC.

SOFTWARE

Leading risk calculation software

SOFTWARE
Technician working in laboratory

LifeCycle™ 7.0 software

Vanadis® NIPT system includes System Software and trusted LifeCycle™ software, the complete data management solution for prenatal screening laboratories. With a simple and flexible user interface and a performance monitoring dashboard that enables access from any current Web browser, these software provide the reliability and support laboratories can rely on.

OTHER PLATFORMS

More Prenatal Screening Instruments

Instruments
AutoDELFIA® immunoassay system

AutoDELFIA® immunoassay system

AutoDELFIA® immunoassay system for prenatal & neonatal screening with fully automated batch-loading
VICTOR2™ D fluorometer

VICTOR2™ D fluorometer

Fluorometer designed for clinical use with all PerkinElmer diagnostic and screening assays based on either time-resolved fluorescence or prompt fluorescence.
DELFIA® Xpress random access platform

DELFIA® Xpress random access platform

Random Access immunonanalyzer platform for prenatal screening
RESOURCES

Articles & Resources

RESOURCES
Clinical validation of a novel automated cell‐free DNA screening assay for trisomies 21, 13, and 18 in maternal plasma
Prenatal
19 Aug 2019

Clinical validation of a novel automated cell‐free DNA screening assay for trisomies 21, 13, and 18 in maternal plasma

Ericsson et al., Prenatal Diagnosis. 2019
Prenatal screening for trisomy 21: a comparative performance and cost analysis of different screening strategies
Prenatal
23 Nov 2020

Prenatal screening for trisomy 21: a comparative performance and cost analysis of different screening strategies

Huang et al., BMC Pregnancy and Childbirth, 2020. Provided by the Springer Nature SharedIt content-sharing initiative. No modifications were made on this material. https://creativecommons.org/licenses/by/4.0/
Minimizing Patients’ Risk of Adverse Outcomes in NIPT
Prenatal
26 Sep 2020

Minimizing Patients’ Risk of Adverse Outcomes in NIPT

Lawrence Prensky, MS, LCGC, CCGC, discusses the challenges within NIPT on one of the biggest stages in prenatal health, the CoGEN 2020 World Conference.
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