With our high-throughput Vanadis® NIPT solution, we’re taking all the complexity out of cell-free DNA (cfDNA) testing, making it accessible to more women – and more cost-effective for your laboratory. This breakthrough technology eliminates PCR amplification and gene sequencing, and it’s so easy to use that one laboratory technician can handle 2000 to 20 000 samples per year. Walkaway automation streamlines the process from primary tube to final results. Because the Vanadis system is an easy to use, non-NGS and non-PCR based method, any laboratory can use it.
Streamlined workflow from primary tube to final result
The Vanadis Extract platform automatically performs plasma separation and cfDNA extraction and purification.
Thousands of targeted cfDNA fragments are specifically converted to DNA circles. Circles are converted to fluorescent DNA molecules and labeled with chromosome-specific fluorophores. The labeled fluorescent DNA molecules are deposited to a microfilter plate.
The fluorescent DNA molecules are deposited on the Vanadis View® plate and counted with the Vanadis View® instrument. With image analysis algorithms, the fluorescent DNA molecules are counted for each sample.
The ratio between the number of each chromosome-specific fluorescent DNA molecules is transferred for risk calculation to the LifeCycle™ Prenatal Screening Software, to calculate the likelihood of a trisomy.
Walkaway automation for greater efficiency
With Vanadis technology, all the critical steps are automated, starting with pipetting steps to reduce manual errors. Plasma volumes are monitored by camera to avoid contamination by the buffy coat, and samples and reagents are barcoded for complete tracking throughout the workflow.
No PCR, No sequencing
Vanadis is the only NIPT screening platform to enable targeted cfDNA analysis without PCR, instead directly capturing target fragments and labeling them for counting. A proprietary nanofilter plate then captures labeled molecules for imaging, eliminating the need for data-intensive steps such as DNA sequencing, microarrays, and microfluidics.
Proven clinical performance
Vanadis Core® T21/T18/T13 Reagent Cartridge
Clinical studies have demonstrated that the Vanadis NIPT system could improve detection and false positive rates, while minimizing the number of no-calls. Products comprising the Vanadis NIPT system are CE-marked in vitro diagnostic products in accordance with European directive 98/79/EC.
Leading risk calculation software
LifeCycle™ 7.0 software
Vanadis® NIPT system includes System Software and trusted LifeCycle™ software, the complete data management solution for prenatal screening laboratories. With a simple and flexible user interface and a performance monitoring dashboard that enables access from any current Web browser, these software provide the reliability and support laboratories can rely on.
More Prenatal Screening Instruments
AutoDELFIA® immunoassay system
VICTOR2™ D Fluorometer
Платформа быстрого доступа DELFIA® Xpress
Articles & Resources
Prenatal screening for trisomy 21: a comparative performance and cost analysis of different screening strategies
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